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PRACA PRZEGLĄDOWA
Znaczenie witaminy D w zapobieganiu i leczeniu depresji
 
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Ukryj
1
Uniwersytet Przyrodniczo-Humanistyczny w Siedlcach, Wydział Nauk Medycznych i Nauk o Zdrowiu, Polska
AUTOR DO KORESPONDENCJI
Katarzyna Antosik   

Uniwersytet Przyrodniczo-Humanistyczny w Siedlcach, Wydział Nauk Medycznych i Nauk o Zdrowiu, Polska, Prusa 14, 08-110, SIEDLCE, Polska
 
Med Og Nauk Zdr. 2021;27(2):121–125
 
SŁOWA KLUCZOWE
DZIEDZINY
STRESZCZENIE
Wprowadzenie:
Wyniki badań ostatnich dziesięcioleci wykazują wzrost zachorowalności na chorobę psychiczną, jaką jest depresja. Światowa Organizacja Zdrowia (WHO) szacuje, że zaburzenie to dotyka ok. 264 mln ludzi na całym świecie i w ciągu najbliższych 20 lat stanie się najczęstszym problemem zdrowotnym. W przebiegu tej choroby znaczenie ma wiele czynników i mechanizmów, a jednym z nich może być niedobór witaminy D.

Cel pracy:
Celem pracy był przegląd aktualnej literatury analizującej wpływ niedoboru witaminy D na występowanie objawów depresji oraz możliwości zastosowania jej suplementacji jako jednej z metod leczenia.

Metody przeglądu:
Systematycznego przeglądu badań, opublikowanych od 1 stycznia 2015 do 31 stycznia 2021 roku, dokonano na podstawie przeszukiwania bibliograficznych baz danych takich jak: PubMed oraz Elsevier. Użyto następujących słów kluczowych i ich kombinacji: witamina D, 25-hydroksy-witamina D, depresja, zaburzenia psychiczne, suplementacja witaminą D.

Wyniki:
Badania naukowe dostarczają dowodów na związek pomiędzy niedoborem 25(OH)D w surowicy krwi a zwiększonym ryzykiem wystąpienia depresji bądź nasilenia jej objawów wśród ludzi w różnym wieku. Badacze podkreślają istotną rolę suplementacji witaminą D3 – witamina ta może być stosowana w celu zmniejszenia nasilenia symptomów tego zaburzenia psychicznego lub jako środek wzmacniający leczenie farmakologiczne.

Podsumowanie:
Istnieje potrzeba dalszych badań, w szczególności randomizowanych, które będą w bardziej wiarygodny sposób wyjaśniać znaczenie witaminy D w przebiegu depresji oraz przedstawiać jej kliniczne zastosowanie w leczeniu tej choroby. Miałoby to znaczące korzyści nie tylko dla pojedynczych osób, ale również dla ogółu populacji, przyczyniając się do poprawy zdrowia w społeczeństwie.


Introduction:
The results of recent decades of research show an increase in the incidence of mental disorders, such as depression. The World Health Organization estimates that the disorder affects approximately 264 million people worldwide, and will become the most common health problem in the next 20 years. Many factors and mechanisms play a role in the pathophysiology of this disease, one of which may be vitamin D deficiency.

Objective:
The aim of the study was to review the current literature analyzing the impact of vitamin D deficiency on the occurrence of depression symptoms and the possibility of using its supplementation as one of the methods of treatment.

Review methods:
The systematic review of the research, published from 1 January 2015–31 January 2021, was carried out based on searching bibliographic databases, such as: PubMed and Elsevier. The following key words and their combinations were used: vitamin D, 25-hydroxyvitamin D, depression, mental disorders, and vitamin D supplementation.

Results:
There is scientific evidence for a relationship between deficiency of 25 (OH) D in blood serum and an increased risk of depression, or its exacerbation in people of all ages. Researchers emphasize the important role of vitamin D3 supplementation to reduce the severity of the symptoms of this mental disorder, or to use it as a drug enhancing pharmacological treatment.

Conclusion:
There is a need for further research, in particular randomized studies, which would more reliably explain the importance of vitamin D in the pathophysiology of depression and its clinical application in the treatment of this disease. This would bring about substantial benefits not only for an individual, but also for the general population, contributing to the improvement of the functioning of the public health sec tor.

Kurowska K, Antosik K, Decyk A, Kobylińska M. Znaczenie witaminy D w zapobieganiu i leczeniu depresji. Med Og Nauk Zdr. 2021; 27(2): 121–125. doi: 10.26444/monz/137481
 
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