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Z Katedry i Zakładu Medycyny Rodzinnej Uniwersytetu Medycznego w Lublinie
Med Og. 2009;15(3):341-350
Metabolic syndrome is a clustering of cardiovascular risk factors, with insulin resistance as a major feature. This syndrome has been variously defined, but is most often diagnosed with the presence of three or more of the following components: abdominal obesity, hypertension, hypertriglyceridemia, low HDL, and hyperglycaemia. Visceral adipose tissue plays a key role in the pathogenesis of atherosclerosis and insulin resistance, and is closely linked to vascular inflammation. Evaluating for the presence of subclinical atherosclerosis and inflammatory biomarkers may be helpful in the risk stratification of patients with metabolic syndrome. The primary goals of treatment of metabolic syndrome are prevention of coronary heart disease events and type 2 diabetes, if not already present. The approach to treatment of patients with metabolic syndrome should include lifestyle changes, including weight loss and exercise, as well as appriopriate pharmacological therapies.
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