Introduction and objective:
The review analyzes evidence on oral hydrolyzed collagen peptide supplementation for improving skin hydration, elasticity, and condition, while exploring collagen’s biological role and skin aging mechanisms. Aging alters skin structure and function, especially in the dermal extracellular matrix, where collagen loss, reduced fibroblast activity, and oxidative stress lower elasticity and cause visible aging. Intrinsic aging and UVinduced photoaging accelerate these effects. Given collagen’s role in dermal integrity, interest has grown in hydrolyzed collagen due to its higher bioavailability.

Review methods:
An analysis was conducted of studies published between 2018 – 2024.

Brief description of the state of knowledge:
The review shows that the oral intake of low molecular weight collagen peptides significantly improves skin hydration, elasticity, and reduces wrinkle depth. These effects are linked to enhanced fibroblast activity and increased synthesis of collagen, elastin, and hyaluronic acid. Anti-oxidant and anti-inflammatory actions may also contribute to the benefits. Collagen supplementation appears to be safe and well-tolerated. Current data support its use as a promising dermonutritional strategy to improve skin health and counteract visible aging.

Summary:
Clinical trials support the use of oral hydrolyzed collagen as an effective intervention for age-related skin decline. Supplementation improves hydration, elasticity, density, and wrinkle depth by enhancing peptide absorption and dermal accumulation. The peptides stimulate fibroblasts, boosting collagen, elastin, and glycosaminoglycan synthesis, and provide anti-oxidative and anti-inflammatory effects. Studies report good safety, although more diverse, long-term research is needed to confirm the benefits and optimize use.