6
MNiSW
58.21
ICV
PRACA ORYGINALNA
 
 

WPŁYW INFEKCJI HELICOBACTER PYLORI NA WCHŁANIANIE WITAMINY B 12 Z PRZEWODU POKARMOWEGO

 
1
z Katedry i Kliniki Chorób Wewnętrznych Uniwersytetu Medycznego w Lublinie
MONZ 2009;15(2):268–275
SŁOWA KLUCZOWE:
STRESZCZENIE ARTYKUŁU:
W badaniu podjęto próbę określenia wpływu infekcji Helicobacter pylori błony śluzowej żołądka na wchłanianie witaminy B[sub]12[/sub] z przewodu pokarmowego.

Helicobacter pylori (HP) infection is considered the main cause of chronic active gastritis. Long-lasting infection may lead to atrophic gastritis, which may in turn impair vitamin B[sub]12[/sub] absorption caused by diminished secretions of hydrochloric acid and intrinsic factor (IF). The aim of the present study was to investigate the influence of HP infection on absorption of vitamin B[sub]12[/sub] and secretion of internal factor (IF). The IF secretion was evaluated indirectly by measuring of the area under the curve (AUC) for vitamin B[sub]12[/sub] absorption. Five blood plasma samples were harvested to measure plasma concentration of vitamin B[sub]12[/sub]. This procedure was performed before and 3 weeks after HP eradication. HP infection was confirmed by urease test in endoscopy samples. A total of 30 patients were included to the study. The average concentration of vitamin B[sub]12[/sub] increased from 326 to 412 pg/ml after HP eradication, and the AUC increased from 4643 to 5023 units (p=0.04). In conclusion, it was confirmed that HP infection diminishes vitamin B[sub]12[/sub] absorption and IF secretion.
eISSN:2084-4905
ISSN:2083-4543