Introduction and objective:
Vaccinations are the safest and for many years proven way of acquiring immunity. In the European Union, two mRNA vaccines and two vector vaccines based on modified adenoviruses have been registered for the prevention of COVID-19. Adverse vaccine reactions (AVRs) are any abnormal body reaction or event after vaccination. These reactions can range in severity from mild to rarely occurring serious or even life-threatening. The aim of the study was to evaluate adverse vaccine reactions (AVRs) in patients vaccinated against SARS-COV-2.

Material and methods:
The study was conducted among 376 people using the diagnostic survey method. The inclusion criterion was vaccination against SARS-CoV-2 virus. Due to the lack of standardized tools adapted to the planned research, an author-constructed questionnaire composed of 15 items was used.

Among the respondents, 37.3% received two doses of the vaccine. No vaccine reactions occurred in 47.9% of patients. There was a significant relationship between the age of the respondents [χ2 (2; N=376)=5.74; p<0.05; V=0.24], kidney diseases (p =0.019), the presence of arterial hypertension (p=0.0003), neoplastic diseases (p=0.047), chronic respiratory diseases (p =0.015), the amount of medications taken [χ2 (2; N=376)=5.62; p<0.05; V=0.23], with successive doses of two- dose vaccination [χ2 (2; N=376)=4.23; p<0.05; V=0.34].

The anti-Covid-19 vaccines used, regardless of the mechanism of action, turned out to be safe. AVRs are more common in the elderly suffering from comorbidities and taking 3–5 medications on a regular basis. AVRs are more common after the second dose of the vaccine

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