REVIEW PAPER
Gut microbiota – invaluable guardian of immunity and vitality of the human body
| 1 | Indywidualna Praktyka Lekarska Sabina Ziółkowska, Wrocław, Polska |
| 2 | Absolwentka Uniwersytetu Medycznego im. Piastów Śląskich, Wrocław, Polska |
| 3 | Bio-Orto, NZOZ, Wrocław, Polska |
| 4 | Prywatna Praktyka Lekarska Paulina Kostrzewska, Wrocław, Polska |
CORRESPONDING AUTHOR
Sabina Ziółkowska
Indywidualna Praktyka Lekarska Sabina Ziółkowska, Ołtaszyńska 12, 53-010, Wrocław, Polska
Indywidualna Praktyka Lekarska Sabina Ziółkowska, Ołtaszyńska 12, 53-010, Wrocław, Polska
Med Og Nauk Zdr. 2022;28(1):8–14
KEYWORDS
TOPICS
Biomedyczne aspekty zdrowia i chorobyProfilaktyka chorób i promocja zdrowiaZdrowie środowiskowePsychologia i socjologia zdrowiaŻywność i żywienieCivilization diseases
ABSTRACT
Introduction and objective:
For many years gut microbiota has been an object of interest to scientists. Over the years there have appeared an increasing number of surprising discoveries about the function of gut microbiota and its impact on the human body. These once underestimated prokaryotic organisms, perform a number of functions for a host, including the regulation of metabolism, immunity and the nervous system. The aim of the review was to summarize evidence-based knowledge and the most important health aspects of microbiota relying on the current literature, to emphasize the holistic influence on health, well-being and ageing.
Review methods:
The presented article is a review of current literature concerning the impact of the gut microbiota on human body, carried out based on an English language search of bibliographic database PubMed. The following key words and their combinations were used: ‘microbiota’, ‘diet and microbiota’, ‘gut-brain axis’,’microbiota transplantation’, ‘autoimmune diseases-microbiota’, and ‘ageing and microbiota’.
Abbreviated description of the state of knowledge:
Nowadays it is known that gut microbiota can synthesize not only vitamins, which has been discovered nearly 60 years ago, but being a part of the gut-brain axis, can also synthesize neurotransmitters, and have a direct effect on our behaviour and well-being. It is also known, that the disturbance within the composition or the function of microbiota contributes to morbidity.
Summary:
The role of gut microbiota seems to be greater than has been assumed to-date. Proper diet, everyday physical activity and avoidance of unnecessary antibiotic therapy contribute to the balance of microbiome. Care should be taken of gut microbiota, and the measurable health benefits would be perceived on multiple levels.
For many years gut microbiota has been an object of interest to scientists. Over the years there have appeared an increasing number of surprising discoveries about the function of gut microbiota and its impact on the human body. These once underestimated prokaryotic organisms, perform a number of functions for a host, including the regulation of metabolism, immunity and the nervous system. The aim of the review was to summarize evidence-based knowledge and the most important health aspects of microbiota relying on the current literature, to emphasize the holistic influence on health, well-being and ageing.
Review methods:
The presented article is a review of current literature concerning the impact of the gut microbiota on human body, carried out based on an English language search of bibliographic database PubMed. The following key words and their combinations were used: ‘microbiota’, ‘diet and microbiota’, ‘gut-brain axis’,’microbiota transplantation’, ‘autoimmune diseases-microbiota’, and ‘ageing and microbiota’.
Abbreviated description of the state of knowledge:
Nowadays it is known that gut microbiota can synthesize not only vitamins, which has been discovered nearly 60 years ago, but being a part of the gut-brain axis, can also synthesize neurotransmitters, and have a direct effect on our behaviour and well-being. It is also known, that the disturbance within the composition or the function of microbiota contributes to morbidity.
Summary:
The role of gut microbiota seems to be greater than has been assumed to-date. Proper diet, everyday physical activity and avoidance of unnecessary antibiotic therapy contribute to the balance of microbiome. Care should be taken of gut microbiota, and the measurable health benefits would be perceived on multiple levels.
REFERENCES (72)
1.
Handelsman J, Rondon M R, Brady S F, Clardy J, Goodman R M. Molecular biological access to the chemistry of unknown soil microbes: a new frontier for natural products. Chem Biol. 1998; 5: R245–R249.
2.
Berg G, Rybakova D, Fischer D, et al. Microbiome definition revisited: old concepts and new challenges. Microbiome. 2020; 8, 103. https://doi. org/10.1186/s40168-020-00875-0.
3.
Clavijo V, Florez Mjv. The gastrointestinal microbiome and its asso- ciation with the control of pathogens in broiler chicken production:a review. Poult Sci. 2017; 97: 1006–1021.
4.
Sender R, Fuchs S, Milo R. Are we really vastly outnumbered? Revisiting the ratio of bacterial to host cells in humans. Cell. 2016; 164: 337–340.
5.
Tierney BT, et al. The landscape of genetic content in the gut and oral human microbiome. Cell Host Microbe. 2019; 26, 283–295.e8.
6.
Szabo G. Gut–liver axis in alcoholic liver disease. Gastroenterology 2015; 148, 30–36.
7.
Odamaki T, Kato K, Sugahara H, Hashikura N, Takahashi S, Xiao J, Abe F, Osawa R. Age-related changes in gut microbiota composition from newborn to centenarian: a cross sectional study. BMC Microbiol 2016; 16(1): 90–112.
8.
Nagpal R, Tsuji H, Takahashi T, Nomoto K, Kawashima K, Nagata S, Yamashiro Y. Ontogenesis of the gut microbiota composition in healthy, full-term, vaginally born and breast-fed infants over the first 3 years of life: a quantitative bird’s-eye view. Front Microbiol. 2017; 8: 1388–1400.
9.
Hasan N, Yang H. Factors affecting the composition of the gut micro- biota, and its modulation. Peer. 2019; J: 7–38.
10.
Ursell LK, Clemente JC, Rideout JR, Gevers D, Caporaso JG, Knight R. The interpersonal and intrapersonal diversity of human-associated microbiota in key body sites. J Allergy Clin Immunol. 2012; 129: 1204–1208.
11.
Jethwani P, Grover K. Gut microbiota in health and diseases-a review. Int J Curr Microbiol Appl Sci. 2019; 8(8): 1586–1599.
12.
Mills S, Stanton C, Lane J, Smith G, Ross R. Precision nutrition and the microbiome, Part I: Current state of the science nutrients. 2019; 11: 923–968.
13.
Wiley N, Dinan T, Ross R, Stanton C, Clarke G, Cryan J. The microbiota-gut-brain axis as a key regulator of neural function and the stress response: implications for human and animal health. J Anim Sci. 2017; 95: 3225–3246.
14.
Rothschild D, Weissbrod O, Barkan E, Kurilshikov A, Korem T, Zeevi D, Costea P, Godneva A, Kalka I, Bar N, Shilo S, Lador D, et al. Environment dominates over host genetics in shaping human gut microbiota. Nature 2018; 555: 210–215 n.d.
15.
Kelly C, Zheng L, Campbell E, Saeedi B, Scholz C, Bayless A, Wilson K, Glover L, Kominsky D, Magnuson A, Weir T, et al. Crosstalk between microbiota-derived short-chain fatty acids and intestinal epithelial HIF augments tissue barrier function. Cell Host Microbe 2015; 17(5): 662–671.
16.
Zheng P, Zeng B, Liu M, Chen J, Pan J, Han Y, Liu Y, Cheng K, Zhou C, Wang H, Zhou X, Gui S, Perry S, Wong M, Licinio J, Wei H, Xie P. The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice. Science Adv. 2019; 5(2): 8317–8326.
17.
Bunyavanich S, Shen N, Grishin A, Wood R, Burks W, Dawson P, Jones SM, Leung D, Sampson H, Sicherer S, Clemente J. Early-life gut microbiome composition and milk allergy resolution. J Allergy Clin Immunol. 2016; 138(4): 1122–1130.
18.
Nishino K, Nishida A, Inoue R, Kawada Y, Ohno M, Sakai S, Inatomi O, Bamba S, Sugimoto M, Kawahara M, Naito Y, Andoh A. Analysis of endoscopic brush samples identified mucosa-associated dysbiosis in inflammatory bowel disease. J Gastroenterol. 2018; 53(1): 95–106.
19.
Jie Z, Xia H, Zhong S, Feng Q, Li S, Liang S, Zhong H, Liu Z, Gao Y, Zhao H, Zhang D, Su Z, Fang Z, Lan Z, Li J, Xiao L, Li J, et al. The gut microbiome in atherosclerotic cardiovascular disease. Nat Commun. 2017; 8(1): 845–860.
20.
Chu D, Ma J, Prince A, Antony K, Seferovic M, Aagaard K. Maturation of the infant microbiome community structure and function across multiple body sites and in relation to mode of delivery. Nat Med. 2017; 23(3): 314–326.
21.
Garrett, WS. Cancer and the microbiota. Science. 2015; 348(6230): 80–86. doi: 10.1126/science.aaa4972.
22.
Zimmermann M, Zimmermann-Kogadeeva, M, Wegmann R, Goodman AL. Mapping human microbiome drug metabolism by gut bacteria and their genes. Nature. 2019; 570: 462–467.
23.
Ben-Zvi I, Kivity S, Langevitz P, Shoenfeld Y. Hydroxychloroquine: from malaria to autoimmunity. Clin Rev Allergy Immunol. 2012; 42: 145–153.
24.
Lin L, Zhang J. Role of intestinal microbiota and metabolites on gut homeostasis and human diseases. BMC Immunol. 2017; 18: 837–850.
25.
Thursby E, Juge N. Introduction to the human gut microbiota. Biochem J. 2017; 474: 1823–1836.
26.
Perry R, Peng L, Barry N, Cline G, Zhang D, Cardone R, Petersen K, Kibbey R, Goodman A, Shulman G. Acetate mediates a microbiome-brain-b-cell axis to pro- mote metabolic syndrome. Nature. 2016; 534: 213–217.
27.
LeBlanc J, Milani C, de Giori G, Sesma F, van Sinderen D, Ventura M. Bacteria as vitamin suppliers to their host: a gut bacteria perspective. Curr Opin Biotechnol. 2013; 24: 160–168.
28.
Frick PG, Riedler G, Brögli H. Dose response and minimal daily re- quirement for vitamin K in man. J Appl Physiol. 1967; 23: 387–389.
29.
Sudo N, et al. Postnatal microbial colonization programs the hypotha- lamic–pituitary–adrenal system for stress response in mice. J Physiol. 2004; 558: 263–275.
30.
Aresti Sanz J, El Aidy S. Microbiota and gut neuropeptides: a dual action of antimicrobial activity and neuroimmune response. Psychopharmacology. 2019; 236: 1597–1609.
31.
Strandwitz P, et al. GABA-modulating bacteria of the human gut microbiota. Nat Microbiol. 2019; 4: 396–403.
32.
Yano JM, et al. Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis. Cell. 2015; 161: 264–276.
33.
Morais LH, Schreiber HL, Mazmanian SK. The gut microbiota–brain axis in behaviour and brain disorders. Nature Reviews Microbiology. 2020; doi: 10.1038/s41579-020-00460-0.
34.
Crovesy L, Masterson D, Rosado EL. Profile of the gut microbiota of adults with obesity: a systematic review. European Journal of Clinical Nutrition. 2020); 74(9): 1251–1262.
35.
Kolida A, Syzenko G, Moseiko V, Budovska L, Puchkov K, Perederiy V, et al. Association between body mass index and Firmicutes/Bcateroidetes ratio in an adult Ukranian population. BMC Microbiol. 2017; 17: 120.
36.
Rahat-Rozenbloom S, Fernandes J, Gloor GB, Wolever TM. Evidence for greater production of colonic short-chain fatty acids in overweight than lean humans. Int J Obes. 2014; 38: 1525–31.
37.
Kasai C, Sugimoto K, Moritani I, Tanaka J, Oya Y, Inoue H, et al. Com- parison of the gut microbiota composition between obese and non-obese individuals in a Japanese population, as analyzed by terminal restriction fragment length polymorphism and next- generation sequencing. BMC Gastroenterol. 2015; 15: 100.
38.
Ibrahim M, Anishetty S. A meta-metabolome network of carbo- hydrate metabolism: interactions between gut microbiota and host. Biochem Biophys Res Commun. 2012; 428: 278–84.
39.
Segafredo FB, Blume CA, Moehlecke M, Giongo A, Casagrande DS, Spolidoro JVN, et al. Weight-loss interventions and gut microbiota changes in overweight and obese patients: a systematic review. Obes Rer. 2017; 18: 823–51.
40.
Bach JF. The hygiene hypothesis in autoimmunity: the role of pathogens and commensals. Nat Rev Immunol. 2018; 18: 105–120.
41.
Vatanen T, et al. Variation in microbiome LPS immunogenicity contr- ibutes to autoimmunity in humans. Cell. 2016; 165: 842–853.
42.
Bennet S, Ohman L, Simren M. Gut microbiota as potential orchestra- tors of irritable bowel syndrome. Gut Liver. 2015; 9: 318–931.
43.
Gomaa EZ. Human gut microbiota/microbiome in health and diseases: a review. Antonie van Leeuwenhoek 2020.
44.
Schirmer M, Franzosa E, Lloyd-Price J, McIver R, Schwager T, Poon A, Ananthakrishnan E, Andrews G, Barron K, et al. Dynamics of metatranscription in the inflammatory bowel disease gut microbiome. Nat Microbiol. 2018; 3: 337–346.
45.
Lane E, Zisman T, Suskind D. The microbiota in inflammatory bowel disease: current and therapeutic insights. J Inflamm Res. 2017; 10: 63–73.
46.
Weingarden AR, Vaughn BP. Intestinal microbiota, fecal microbiota transplantation, and inflammatory bowel disease. Gut Microbes. 2017; 8(3): 238–252. doi: 10.1080/19490976.2017.129075.
47.
Lopez-Serrano P, Perez-Calle JL, Perez-Fernandez MT, et al. Environmental risk factors in inflammatory bowel diseases. Investigating the hygiene hypothesis: a Spanish case-control study. Scand J Gastroenterol. 2010; 45: 1464–71.
48.
Betrapally N, Gillevet P, Bajaj J. Changes in the intestinal microbiome and alcoholic and nonalcoholic liver diseases: causes or effects? Gastroenterology. 2016; 150: 1745–1770.
49.
Vuitton D, Dalphin J. From farming to engineering: the microbiota and allergic diseases. Engineering. 2017; 3: 98–109.
50.
Frati F, Salvatori C, Incorvaia C, Bellucci A, Di G, Marcucci F, Esposito S. The role of the microbiome in asthma: the gut–lung axis. Int J Mol Sci. 2019; 20: 123–135.
51.
Durack J, Kimes N, Lin D, Rauch M, McKean M, McCauley K, Panzer A, Mar J, Cabana M, Lynch SV. Delayed gut microbiota development in high-risk for asthma infants is temporarily modifiable by Lactobacillus supplementation. Nat Commun. 2018; 9: 707–720.
52.
Schuijs M, Willart M, Vergote K, Gras D, Deswarte K, Ege M, Madeira F, Beyaert R, van Loo G, Bracher F, et al. Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cell. Science. 2015; 349: 1106–1110.
53.
Stokholm J, Blaser M, Thorsen J, Rasmussen M, Waage J, Vinding R, Schoos A, Kunoe A, Fink N, Chawes B, et al. Maturation of the gut microbiome and risk of asthma in childhood. Nat Commun. 2018; 9: 141–152.
54.
Soenen S, Rayner CK, Jones KI, Horowitz M. The ageing gastrointestinal tract. Curr Opin Clin Nutr Metab Care. 2016; 19: 12–18.
55.
Claesson Mj, Cusack S, O’Sullivan O, Greene-diniz R, de Weerd H, Flannery E, Marchesi JR, Falush D, Dinan T, Fitzgerald G, Stanton C, Van Sinderen D, O’Connor M, Harnedy N, O’Connor K, Henry C, O’Mahony D, Fitzgerald AP, Shanahan F, Twomey C, Hill C, Ross RP, O’toole PW. Composition, variability, and temporal stability of the intestinal microbiota of the elderly. Proc Natl Acad Sci USA. 2011; 108: 4586–4591.
56.
Franceschi C, Campisi J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci. 2014; 69: S4–9.
57.
Mangiola F, Nicoletti A, Gasbarrini A, Ponziani FR. Gut microbiota and aging Eur Rev Med Pharmacol Sci. 2018; 22(21): 7404–7413. doi: 10.26355/eurrev_201811_16280.
59.
Arboleya S, Watkins C, Stanton C, Ross RP. Gut bifidobacteria po- pulations in human health and aging. Front Microbiol. 2016; 7: 1204.
60.
Clarke SF, Murphy EF, O’Sullivan O, et al. Exercise and associated dietary extremes impact on gut microbial diversity. Gut. 2014; 63(12): 1913–1920.
61.
Zmora N, Suez J,Elinav E. You are what you eat: diet, health and the gut microbiota. Nature Reviews Gastroenterology & Hepatology. 2018. doi: 10.1038/s41575-018-0061-2.
62.
David LA, Maurice CF, Carmody RN, et al. Diet rapidly and repro- ducibly alters the human gut microbiome. Nature. 2014; 505: 559–63.
63.
Albenberg LG, Wu GD. Diet and the intestinal microbiome: associa- tions, 9 functions, and implications for health and disease. Gastroenterology. 2014; 146: 1564–72.
64.
Russell WR, Gratz SW, Duncan HS, et al. High-protein, reducedcarbohydrate weight-loss diets promote metabolite profiles likely to be detrimental to colonic health. Am J Clin Nutr. 2011; 93: 1062–72. 2.
65.
Sanders ME, Merenstein DJ, Reid G, Gibson GR, Rastall RA. Probiotics and prebiotics in intestinal health and disease: from biology to the clinic. Nature Reviews Gastroenterology & Hepatology. 2019; doi: 10.1038/ s41575-019-0173-3.
66.
Gibson GR, et al. Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nat Rev Gastroente- rol Hepatol. 2017; 14: 491–502. https://doi.org/10.1038/nrgast....
67.
Meyer D, Stasse-Wolthuis M. The bifidogenic effect of inulin and oli- gofructose and its consequences for gut health. Eur J Clin Nutr. 2009;63: 1277–1289. https://doi.org/10.1038/ejcn.2....
68.
Chen M, et al. Dairy consumption and risk of type 2 diabetes: 3 cohorts of US adults and an updated meta-analysis. BMC Med. 2014; 12: 215.
69.
Fukuda S, et al. Bifidobacteria can protect from enteropathogenic in fection through production of acetate. Nature. 2011; 469, 543.
70.
Glassner KL, Abraham BP, Quigley EMM. The microbiome and inflam- matory bowel disease. Journal of Allergy and Clinical Immunology. 2020; 145(1): 16–27. doi: 10.1016/j.jaci.2019.11.003.
71.
Dasgupta S, Kasper DL. Relevance of commensal microbiota in the treatment and prevention of inflammatory bowel disease. Inflamm Bowel Dis. 2013; 19: 2478–89.
72.
Khoruts A, Weingarden AR. Emergence of fecal microbiota trans- plantation as an approach to repair disrupted microbial gut ecology. Immunol Lett. 2014; 162: 77–81.
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