RESEARCH PAPER
Analysis of cortisol levels in breast milk and blood serum in women with symptoms of postpartum depression
1
Department of Perinatology, Gynaecology and Gynaecologic Oncology, Faculty of Health Sciences, Ludwik Rydygier Collegium Medicum, Bydgoszcz, Nicolaus Copernicus University, Toruń, Poland
2
Department of Gynaecology and Obstetrics, Ludwik Błażek Multispecialist Hospital, Inowrocław, Poland
3
Department of Pathobiochemistry and Clinical Chemistry, Faculty of Pharmacy, Ludwik Rydygier Collegium Medicum, Bydgoszcz, Nicolaus Copernicus University, Toruń, Poland
Corresponding author
Agnieszka Dombrowska-Pali
Katedra Perinatologii, Ginekologii i Ginekologii Onkologicznej, Wydział Nauk o Zdrowiu, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy, Uniwersytet Mikołaja Kopernika w Toruniu, Łukasiewicza 1, 85-821, Bydgoszcz, Polska
Katedra Perinatologii, Ginekologii i Ginekologii Onkologicznej, Wydział Nauk o Zdrowiu, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy, Uniwersytet Mikołaja Kopernika w Toruniu, Łukasiewicza 1, 85-821, Bydgoszcz, Polska
Med Og Nauk Zdr. 2022;28(2):165–171
KEYWORDS
postpartum depressionbreastfeedingEdinburgh Postpartum Depression Scalemilk cortisolserum cortisol concentration
TOPICS
ABSTRACT
Introduction and objective:
Scientific studies report that the risk of symptoms of postpartum depression (PPD) can significantly reduce breastfeeding time. It has not yet been shown whether there is a difference in cortisol levels in breast milk and serum cortisol levels in women at risk of PPD but without symptoms. The aim of the study was assessment of the levels of cortisol in breast milk and levels of serum cortisol in women at risk of PPD four weeks after birth.
Material and methods:
The study included 75 women who were recruited at a University Hospital and via social media. The proper study was conducted in the fourth week after delivery. The research tool used was The Edinburgh Postnatal Depression Scale (EPDS). Assessment of cortisol levels in breast milk was performed with the enzyme-linked immunosorbent assay CORTISOL saliva ELISA DiaMetra. Blood analysis was conducted in an ALAB Laboratory, one of a nationwide network of specialis laboratories.
Results:
The prevalence of the risk of PPD symptoms in the study sample was estimated at 28% in EPDS. The risk of PPD symptoms does not differentiate between cortisol levels in breast milk and serum cortisol levels (p>0.05). A correlation was shown between the level of cortisol in breast milk and in the blood serum of the study sample (p<0.03).
Conclusions:
The study indicates that the risk of PPD symptoms does not differentiate between serum cortisol levels and cortisol levels in breast milk. The level of cortisol in breast milk reflects the level of cortisol in the blood serum of the subjects.
Scientific studies report that the risk of symptoms of postpartum depression (PPD) can significantly reduce breastfeeding time. It has not yet been shown whether there is a difference in cortisol levels in breast milk and serum cortisol levels in women at risk of PPD but without symptoms. The aim of the study was assessment of the levels of cortisol in breast milk and levels of serum cortisol in women at risk of PPD four weeks after birth.
Material and methods:
The study included 75 women who were recruited at a University Hospital and via social media. The proper study was conducted in the fourth week after delivery. The research tool used was The Edinburgh Postnatal Depression Scale (EPDS). Assessment of cortisol levels in breast milk was performed with the enzyme-linked immunosorbent assay CORTISOL saliva ELISA DiaMetra. Blood analysis was conducted in an ALAB Laboratory, one of a nationwide network of specialis laboratories.
Results:
The prevalence of the risk of PPD symptoms in the study sample was estimated at 28% in EPDS. The risk of PPD symptoms does not differentiate between cortisol levels in breast milk and serum cortisol levels (p>0.05). A correlation was shown between the level of cortisol in breast milk and in the blood serum of the study sample (p<0.03).
Conclusions:
The study indicates that the risk of PPD symptoms does not differentiate between serum cortisol levels and cortisol levels in breast milk. The level of cortisol in breast milk reflects the level of cortisol in the blood serum of the subjects.
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