PL EN
REVIEW PAPER
Figure from article: A review of literature...
 
KEYWORDS
TOPICS
ABSTRACT
Introduction and objective:
Substances that can imitate natural hormones in the body are known as endocrinedisrupting chemicals (EDCs). Women are commonly exposed to EDCs from materials that come into contact with food and personal care products. The aim of this review is to present the current data covering the years 2020–2026 on the impact of EDCs on women's health.

Review methods:
To facilitate the literature review, the PubMed database was searched using the following search terms: ‹female reproductive health AND endocrine disruptors›, ‹women's reproductive health AND EDCs›, ‹pregnancy exposure AND endocrine disrupting chemicals›, ‹pregnancy exposure AND EDCs›, ‹female reproductive health AND EDCs›. Articles not related to the topic were excluded during the preliminary review of summaries. A total of 17 studies published between 2016–2026 were finally analysed. in the end.

Brief description of the state of knowledge:
EDC substances disrupt the binding of hormones to their respective receptors, particularly the estrogen and androgen receptors, resulting in agonistic or antagonistic effects. Consequently, EDCs may have a negative effect on reproductive functions. This includes reducing the ovarian reserve and increases the risk of infertility.

Summary:
In scientific publications, the significant impact of EDC on health is emphasized, and there is therefore a need to continue research, including using advanced methods for detecting and measuring EDC mixtures.
REFERENCES (39)
1.
Ghosh A, Tripathy A, Ghosh D. Impact of Endocrine Disrupting Chemicals (EDCs) on Reproductive Health of Human. Proc Zool Soc. 2022;75(1):16–30. https://doi.org/10.1007/s12595....
 
2.
Interdonato L, Siracusa R, Fusco R, et al. Endocrine Disruptor Compounds in Environment: Focus on Women’s Reproductive Health and Endometriosis. Int J Mol Sci. 2023;24(6):5682. https://doi.org/10.3390/ijms24....
 
3.
Guarnotta V, Amodei R, Frasca F, et al. Impact of Chemical Endocrine Disruptors and Hormone Modulators on the Endocrine System. Int J Mol Sci. 2022;23(10):5710. https://doi.org/10.3390/ijms23....
 
4.
Onyime SC, Nworie FS. Endocrine-Disrupting Chemicals: Environmental Impact, Exposure Pathways, and Human Health Risks – A Review. Chemistry Africa. 2026;9(1). https://doi.org/10.1007/s42250....
 
5.
Haggerty DK, Upson K, Pacyga DC, et al. REPRODUCTIVE TOXICOLOGY: Pregnancy exposure to endocrine disrupting chemicals: implications for women’s health. Reproduction. 2021;162(5):F169–F180. https://doi.org/10.1530/REP-21....
 
6.
van Duursen MBM, Boberg J, Christiansen S, et al. Safeguarding Female Reproductive Health Against Endocrine Disrupting Figure 1. Overview of sources, routes and effects of EDCs on women's health Chemicals—The FREIA Project. Int J Mol Sci. 2020;21(9):3215. https://doi.org/10.3390/ijms21....
 
7.
Piazza MJ, Urbanetz AA. Environmental toxins and the impact of other endocrine disrupting chemicals in women’s reproductive health. JBRA Assist Reprod. 2019;23(2):154–164. https://doi.org/10.5935/1518-0....
 
8.
Yilmaz B, Terekeci H, Sandal S, et al. Endocrine disrupting chemicals: exposure, effects on human health, mechanism of action, models for testing and strategies for prevention. Rev Endocr Metab Disord. 2020;21(1):127–47. https://doi.org/10.1007/s11154....
 
9.
Gore AC, Chappell VA, Fenton SE, et al. EDC-2: The Endocrine Society’s Second Scientific Statement on Endocrine-Disrupting Chemicals. Endocr Rev. 2015;36(6):E1–E150. https://doi.org/10.1210/er.201....
 
10.
Rehman S, Usman Z, Rehman S, et al. Endocrine disrupting chemicals and impact on male reproductive health. Transl Androl Urol. 2018;7(3):490–503. https://doi.org/10.21037/tau.2....
 
11.
Brehm E, Flaws JA. Transgenerational Effects of Endocrine-Disrupting Chemicals on Male and Female Reproduction. Endocrinology. 2019;160(6):1421–35. https://doi.org/10.1210/en.201....
 
12.
Cabry R, Merviel P, Madkour A, et al. The impact of endocrine disruptor chemicals on oocyte/embryo and clinical outcomes in IVF. Endocr Connect. 2020;9(6):R134–R142. https://doi.org/10.1530/EC-20-....
 
13.
Cimmino I, Oriente F, D'Esposito V, et al. Low-dose Bisphenol-A regulates inflammatory cytokines through GPR30 in mammary adipose cells. J Mol Endocrinol. 2019;63(4):273–283. https://doi.org/10.1530/JME-18....
 
14.
Kowalska K, Habrowska-Górczyńska DE, Domińska K, et al. ERβ and NFκB-Modulators of Zearalenone-Induced Oxidative Stress in Human Prostate Cancer Cells. Toxins. 2020;12(3):199. https://doi.org/10.3390/toxins....
 
15.
Xie M, Liang JL, Huang HD, et al. Low Doses of Nonylphenol Promote Growth of Colon Cancer Cells through Activation of ERK1/2 via G Protein‒Coupled Receptor 30. Cancer Res Treat. 2019;51(4):1620–1631. https://doi.org/10.4143/crt.20....
 
16.
La Merrill MA, Vandenberg LN, Smith MT, et al. Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification. Nat Rev Endocrinol. 2020;16(1):45–57. https://doi.org/10.1038/s41574....
 
17.
López-Rodríguez D, Aylwin CF, Delli V, et al. Multi- and Transgenerational Outcomes of an Exposure to a Mixture of Endocrine-Disrupting Chemicals (EDCs) on Puberty and Maternal Behavior in the Female Rat. Environ Health Perspect. 2021;129(8):87003. https://doi.org/10.1289/EHP879....
 
18.
den Braver-Sewradj SP, van Spronsen R, Hessel EVS. Substitution of bisphenol A: a review of the carcinogenicity, reproductive toxicity, and endocrine disruption potential of alternative substances. Crit Rev Toxicol. 2020;50(2):128–147. https://doi.org/10.1080/104084....
 
19.
Viguié C, Mhaouty-Kodja S, Habert R, et al. Evidence-based adverse outcome pathway approach for the identification of BPA as en endocrine disruptor in relation to its effect on the estrous cycle. Mol Cell Endocrinol. 2018;475:10–28. https://doi.org/10.1016/j.mce.....
 
20.
Hossein Rashidi B, Amanlou M, Behrouzi Lak T, et al. The Association Between Bisphenol A and Polycystic Ovarian Syndrome: A Case-Control Study. Acta Med Iran. 2018;55(12):759–764.
 
21.
Krawczyk K, Marynowicz W, Gogola-Mruk J, et al. A mixture of persistent organic pollutants detected in human follicular fluid increases progesterone secretion and mitochondrial activity in human granulosa HGrC1 cells. Reprod Toxicol. 2021;104:114–124. https://doi.org/10.1016/j.repr....
 
22.
Li J, Zhou L, Huang S, Duan T, et al. Effect of endocrine-disrupting chemicals in follicular fluid: The insights from oocyte to fertilization. Environ Int. 2024;191:108957. https://doi.org/10.1016/j.envi....
 
23.
Tian T, Hao Y, Wang Y, et al. Mixed and single effects of endocrine disrupting chemicals in follicular fluid on likelihood of diminished ovarian reserve: A case-control study. Chemosphere. 2023;330:138727. https://doi.org/10.1016/j.chem....
 
24.
Wei X, Zhang N, Zhu Q, et al. Exposure to Multiple Endocrine-Disrupting Chemicals and Associations with Female Infertility: A Case-Control Study. Environ Health (Wash). 2024;2(12):902–911. https://doi.org/10.1021/envhea....
 
25.
Birks L, Casas M, Garcia AM, et al. Occupational Exposure to Endocrine-Disrupting Chemicals and Birth Weight and Length of Gestation: A European Meta-Analysis. Environ Health Perspect. 2016;124(11):1785–1793. https://doi.org/10.1289/EHP208.
 
26.
Deji Z, Liu P, Wang X, et al. Association between maternal exposure to perfluoroalkyl and polyfluoroalkyl substances and risks of adverse pregnancy outcomes: A systematic review and meta-analysis. Sci Total Environ. 2021;783:146984. https://doi.org/10.1016/j.scit....
 
27.
Wu Y, Wang J, Wei Y, et al. Maternal exposure to endocrine disrupting chemicals (EDCs) and preterm birth: A systematic review, meta-analysis, and meta-regression analysis. Environ Pollut. 2022;292(Pt A):118264. https://doi.org/10.1016/j.envp....
 
28.
Sun M, Cao X, Wu Y, et al. Prenatal exposure to endocrine-disrupting chemicals and thyroid function in neonates: A systematic review and meta-analysis. Ecotoxicol Environ Saf. 2022;231:113215. https://doi.org/10.1016/j.ecoe....
 
29.
Liu B, Lu X, Jiang A, et al. Influence of maternal endocrine disrupting chemicals exposure on adverse pregnancy outcomes: A systematic review and meta-analysis. Ecotoxicol Environ Saf. 2024;270:115851. https://doi.org/10.1016/j.ecoe....
 
30.
Yang Z, Zhang J, Wang M, et al. Prenatal endocrine-disrupting chemicals exposure and impact on offspring neurodevelopment: A systematic review and meta-analysis. Neurotoxicology. 2024;103:335–357. https://doi.org/10.1016/j.neur....
 
31.
Jiang TT, Zhang DY, Liu ZY, et al. Association of co-exposure to EDCs in early pregnancy with threatened abortion: The mediation effect of progesterone. Environ Int. 2026;207:110001. https://doi.org/10.1016/j.envi....
 
32.
Ihenacho U, Guillermo C, Wilkens LR, et al. Association of Endocrine Disrupting Chemicals With the Metabolic Syndrome Among Women in the Multiethnic Cohort Study. J Endocr Soc. 2023;7(12):bvad136. https://doi.org/10.1210/jendso....
 
33.
Hu Y, Wen S, Yuan D, et al. The association between the environmental endocrine disruptor bisphenol A and polycystic ovary syndrome: a systematic review and meta-analysis. Gynecol Endocrinol. 2018;34(5):370–377. https://doi.org/10.1080/095135....
 
34.
Cardenas A, Hauser R, Gold DR, et al. Association of Perfluoroalkyl and Polyfluoroalkyl Substances With Adiposity. JAMA Netw Open. 2018;1(4):e181493. https://doi.org/10.1001/jamane....
 
35.
Chitakwa N, Alqudaimi M, Sultan M, et al. Plastic-related endocrine disrupting chemicals significantly related to the increased risk of estrogen-dependent diseases in women. Environ Res. 2024;252(Pt 2):118966. https://doi.org/10.1016/j.envr....
 
36.
Zhang H, Zhou H, Chen X, et al. Phthalate exposure as a hidden risk factor for uterine leiomyoma in adult women: Accumulated evidence from observational studies. Ecotoxicol Environ Saf. 2024;285:117069. https://doi.org/10.1016/j.ecoe....
 
37.
Ahn C, Jeung E-B. Endocrine-Disrupting Chemicals and Disease Endpoints. Int J Mol Sci. 2023;24(6):5342. https://doi.org/10.3390/ijms24....
 
38.
Kozieł-Leszczyńska MJ, Piastowska-Ciesielska AW. Bisphenols and their role in female infertility and hormone-related cancer. Endocrine. 2026;91:32. https://doi.org/10.1007/s12020....
 
39.
Conley JM, Lambright CS, Evans N, et al. A mixture of 15 phthalates and pesticides below individual chemical no observed adverse effect levels (NOAELs) produces reproductive tract malformations in the male rat. Environ Int. 2021;156:106615. https://doi.org/10.1016/j.envi....
 
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