RESEARCH PAPER
Immunologic parameters and results of lung function tests in selected pulmonary diseases taking course with fibrosis
1
Z Kliniki Pneumonologii, Onkologii i Alergologii UM w Lublinie
2
Z Zakładu Badań Czynnościowych Instytutu Medycyny Wsi w Lublinie
3
Z Samodzielnego Publicznego Szpitala Klinicznego Nr 1 w Lublinie
4
Z Samodzielnej Pracowni Biologii Molekularnej Instytutu Medycyny Wsi im. W. Chodźki w Lublinie; Z Katedry Zdrowia Publicznego WyŜszej Szkoły Informatyki i Zarządzania w Rzeszowie
5
Z Kliniki Pneumonologii, Onkologii i Alergologii UM w Lublinie; Z Samodzielnej Pracowni Chorób Fibroproliferacyjnych Instytutu Medycyny Wsi im. W. Chodźki w Lublinie
Med Og. 2010;16(1):1–13
KEYWORDS
ABSTRACT
The objective of the study was the evaluation of the differences in diffusion capacity and spirometric test in patients with selected parenchymal lung diseases, and determination of the relationship observed in immune profile at the site of pathological process in progress with changes in lung function. Parenchymal lung disease was diagnosed in a group of 25 patients based on clinical, radiologic and histopathologic examinations. In addition, spirometric test was performed, and single-breath carbon monoxide diffusing capacity (DLCO) with the measurement of the total diffusing capacity of the whole lung and residual volume by the method of He dilution. In all the patients examined bronchoscopy was also performed with bronchoalveolar lavage, and the analysis of leukocyte phenotypes in bronchoalveolar lavage fluid by means of monoclonal antibodies with the use
of flow cytometer. For all the groups analysed a statistically significant relationship was noted between the type of parenchymal disease diagnosed and reduction in lung diffusion capacity. In addition, significant positive correlations were confirmed between the percentage of macrophages in bronchoalveolar lavage fluid and alveolar flow, and between the percentage of T-helper lymphocytes and maximum expiratory flow.
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