REVIEW PAPER
Behaviour disorders and psychotic symptoms in liver diseases – a review article
 
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Klinika Chorób Wewnętrznych, Uniwersytet Medyczny, Lublin
CORRESPONDING AUTHOR
Andrzej Prystupa
Katedra i Klinika Chorób Wewnętrznych, Uniwersytet Medyczny w Lublinie, ul. Staszica 16, 20-081 Lublin
 
Med Og Nauk Zdr. 2013;19(2):135–137
KEYWORDS
ABSTRACT
Introduction:
Hepatic encephalopathy (HE) is a reversible, neuropsychiatric complication of acute or chronic liver failure. Advancement of encephalopathy is defined by the West-Haven scale which distinguishes five degrees of severity (0–4). Clinically, overt HE is preceded by minimal alterations of cerebral function, only detectable by neuropsychological or neurophysiological measures, but which, nevertheless, interfere with the patient’s daily living. Importantly, minimal hepatic encephalopathy (MHE) has a profound negative impact on the ability to drive a car and may be a significant factor behind motor vehicle accidents. Detection and treatment of MHE has the potential to reduce costs associated with motor vehicle accidents. The earliest prognostic signs of hepatic encephalopathy include circadian dysfunction of the sleep and wakefulness rhythm, such as insomnia at night and drowsiness during the day. Sleep disturbances have recently been shown to be an important prognostic factor in patients with advanced chronic liver disease. Although mental changes are frequent in Wilson’s disease, severe psychiatric disorders occur uncommonly and usually accompany the neurological symptoms. There are few reports in the literature of Wilson’s disease patients with typical bipolar affective disorder (BPAD). Key words: hepatic encephalopathy, sleep disorders, Wilson’s disease

 
REFERENCES (14)
1.
Weissenborn K, Bokemeyer M, Krause J, Ennen J, Ahl B. Neurological and neuropsychiatric syndromes associated with liver disease. AIDS. 2005; 19 Suppl 3: S93–8.
 
2.
Jasmohan S Bajaj. World J. Minimal hepatic encephalopathy matters in daily life. Gastroenterol. 2008; 14(23): 3609–3615.
 
3.
Stewart CA, Enders FT, Schneider N, Felmlee-Devine D, Kamath PS, Smith GE. Development of a three-factor neuropsychological approach for detecting minimal hepatic encephalopathy. Liver Int. 2010l; 30(6): 841–9.
 
4.
Kircheis G, Knoche A, Hilger N, Manhart F, Schnitzler A, Schulze H, Häussinger D. Hepatic encephalopathy and fitness to drive Gastroenterology. 2009; 137(5): 1706–15.
 
5.
Bajaj JS, Pinkerton SD, Sanyal AJ, Heuman DM. Diagnosis and treatment of minimal hepatic encephalopathy to prevent motor vehicle accidents: a cost-effectiveness analysis. Hepatology. 2012; 55(4): 1164–71.
 
6.
De Rui M, Schiff S, Aprile D, Angeli P, Bombonato G, Bolognesi M, Sacerdoti D, Gatta A, Merkel C, Amodio P, Montagnese S. Excessive daytime sleepiness and hepatic encephalopathy: it is worth asking. Metab Brain Dis. 2012 Nov 18.
 
7.
De Cruz S, Espiritu JR, Zeidler M, Wang TS. Sleep disorders in chronic liver disease. Semin Respir Crit Care Med. 2012; 33(1): 26–35.
 
8.
Mostacci B, Ferlisi M, Baldi Antognini A, Sama C, Morelli C, Mondini S, Cirignotta F. Sleep disturbance and daytime sleepiness in patients with cirrhosis: a case control study. Neurol Sci. 2008; 29(4): 237–40.
 
9.
Newton JL, Gibson GJ, Tomlinson M, Wilton K, Jones D. Fatigue in primary biliary cirrhosis is associated with excessive daytime somnolence. Hepatology. 2006; 44(1): 91–8.
 
10.
Franco RA, Ashwathnarayan R, Deshpandee A, Knox J, Daniel J, Eastwood D, Franco J, Saeian KJ. The high prevalence of restless legs syndrome symptoms in liver disease in an academic-based hepatology practice. Clin Sleep Med. 2008; 4(1): 45–9.
 
11.
Carta M, Mura G, Sorbello O, Farina G, Demelia L. Quality of Life and Psychiatric Symptoms in Wilson’s Disease: the Relevance of Bipolar Disorders. Clin Pract Epidemiol Ment Health. 2012; 8: 102–9.
 
12.
Machado AC, Deguti MM, Caixeta L, Spitz M, Lucato LT, Barbosa ER. Mania as the first manifestation of Wilson’s disease. Bipolar Disord. 2008; 10(3): 447–50.
 
13.
Spyridi S, Diakogiannis I, Michaelides M, Sokolaki S, Iacovides A, Kaprinis G. Delusional disorder and alcohol abuse in a patient with Wilson’s disease. Gen Hosp Psychiatry. 2008; 30(6): 585–6.
 
14.
Kumawat BL, Sharma CM, Tripathi G, Ralot T, Dixit S. Wilson’s disease presenting as isolated obsessive-compulsive disorder. Indian J Med Sci. 2007; 61(11): 607–10.
 
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