The NMDA receptor ligands in anti-depressant therapy
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Katedra i Zakład Fizjologii Człowieka, Uniwersytet Medyczny w Lublinie
Katedra i Zakład Farmacji Stosowanej, Uniwersytet Medyczny w Lublinie
Weronika Stasiuk   

Katedra i Zakład Fizjologii Człowieka, Uniwersytet Medyczny w Lublinie, ul. Radziwiłłowska 11, 20-080 Lublin
Med Og Nauk Zdr. 2016;22(3):176–180
A new direction in research on depressive disorders focuses on reducing the activity of the NMDA receptor, which opens up new possibilities for the treatment of diseases caused by the excessive activity of the glutamatergic system.

The aim of this work is the study of ligands (especially antagonists) of the NMDA receptor, which influence its expression and function as well as their impact on the action of classic anti-depressant medications.

Description of the state of knowledge:
The effectiveness of currently utilized depressive disorder treatment methods is unsatisfactory and linked to many side effects. It is also a worrying fact that many patients develop drug resistance. This is why there is a continued effort for the development of newer, more effective treatment methods. It has been shown that one of the key anti-depressant mechanisms of action is through the blockage of the NMDA receptor.

The introduction into the treatment regime of antagonists of the NMDA receptor opens new therapeutic possibilities in the treatment of depressive disorders, as well as being a potential alternative in the treatment of drug resistant forms of the disease.

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