RESEARCH PAPER
THE INFLUENCE OF HELICOBACTER PYLORI INFECTION ON VITAMIN B12 ABSORPTION FROM THE GASTROINTESTINAL TRACT
 
More details
Hide details
1
z Katedry i Kliniki Chorób Wewnętrznych Uniwersytetu Medycznego w Lublinie
 
Med Og. 2009;15(2):268–275
 
KEYWORDS
ABSTRACT
Helicobacter pylori (HP) infection is considered the main cause of chronic active gastritis. Long-lasting infection may lead to atrophic gastritis, which may in turn impair vitamin B12 absorption caused by diminished secretions of hydrochloric acid and intrinsic factor (IF). The aim of the present study was to investigate the influence of HP infection on absorption of vitamin B12 and secretion of internal factor (IF). The IF secretion was evaluated indirectly by measuring of the area under the curve (AUC) for vitamin B12 absorption. Five blood plasma samples were harvested to measure plasma concentration of vitamin B12. This procedure was performed before and 3 weeks after HP eradication. HP infection was confirmed by urease test in endoscopy samples. A total of 30 patients were included to the study. The average concentration of vitamin B12 increased from 326 to 412 pg/ml after HP eradication, and the AUC increased from 4643 to 5023 units (p=0.04). In conclusion, it was confirmed that HP infection diminishes vitamin B12 absorption and IF secretion
 
REFERENCES (10)
1.
Carmel R., Perez- Perez G.I., Blaster M.J.: Helicobacter pylori infection and food- cobalamin malabsorption. Dig Dis Sci 1994, 39, 309-314.
 
2.
Chanarin I.: The megaloblastic anemias. Ed 2. Boston, MA: Blackwell Scientific Publications Inc 1979.
 
3.
Baik H.W., Russell R.M.: Vitamin B 12 deficiency in the elderly. Ann Rev Nutr 1999, 19, 357-377.
 
4.
Basso D., Gallo N., Zambon C.F., Baron M., Navaglia F., Stockreiter E.: Antigastric autoantibodies in Helicobacter pylori infection: role in gastric mucosal inflammation. Int J Clin Laboratory Res 2000, 30, 173-178.
 
5.
Kuipres E.J., Klinkenberg E.C.: Helicobacter pylori, acid, and omeprazole revisited: bacterial eradication and rebound hypersecretion. Gastroenterology 1999, 116, 476- 83.
 
6.
Serin E., Gumurdulu Y., Ozer B., Kayaselcuk F., Yilmaz U., Kocak R.: Impact of Helicobacter pylori on the development of vitamin B12 deficiency in the absence of gastric atrophy. Helicobacter 2002, 7, 337-341.
 
7.
Shao J., Sartor R.B., Dial E., Lichtenberger L.M., Schepp W., Alpers D.H.: Expression of intrinsic factor in rat and murine gastric mucosal cell linnages is modified by inflammation. Am J Pathol 2000, 157, 1197-205.
 
8.
Suerbaum S., Michetti P.: Helicobacter pylori infection. N Engl J Med 2002, 347, 1175-1186.
 
9.
Suster PM, Golner BB, Goldin BR, Morrow FD, Russell R.M.: Reversal of protein – bound vitamin B12 malabsorption with antibiotics in atrophic gastritis. Gastroenterology 1991, 101, 1039-1045.
 
10.
Toh B.H., van Driel I.R., Gleeson P.A.: Pernicous Anemia. N Engl J Med 1997, 337, 1441-1448.
 
eISSN:2084-4905
ISSN:2083-4543