Experimental therapies of articular lesions in patients with rheumatoid arthritis
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Centrum Medyczne, Kraków
Zakład Genoterapii, Collegium Medicum, Uniwersytet Mikołaja Kopernika, Bydgoszcz
Piotr Kopiński   

Zakład Genoterapii, Collegium Medicum, Uniwersytet Mikołaja Kopernika, ul. Marii Skłodowskiej-Curie 9, 85-094 Bydgoszcz,
Med Og Nauk Zdr. 2016;22(2):98–103
Rheumatoid arthritis (RA) is one of the most common autoimmune diseases affecting connective tissue. It is characterized by inflammation of the joints leading to progressive damage and loss of joint function, and subsequently to physical disability of the patient.

The aim of the article is to provide an overview of the experimental RA therapies of articular lesions that are currently in early and advanced stages of clinical development.

Brief description:
RA management is presently based on symptomatic treatment, taking biological and synthetic disease-modifying antirheumatic drugs (DMARDs), physiotherapy and surgical correction of articular complications. There are many drugs currently under investigation, such as immune and gene therapy, platelet rich plasma intraarticular injections, application of mesenchymal stem cells, as well as a combination of techniques listed above.

Over the last few years, the rapid progress in RA treatment has been made by introduction of biological treatment. However, no satisfactory clinical response is observed in a significant group of patients, despite the long-term conventional treatment. Hopefully, the techniques described briefly in this review targeting molecular pathomechanisms, are believed to be useful in finding solutions in the treatment of RA articular lesions.

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